Experimental and Simulated Investigation on the Effect of Chemically Retarded Acid Systems in Carbonates

In carbonate acidizing, wormhole development is crucial to the stimulation result. The acid reactivity and injection rate both play important roles in this process. Because the reactivity of HCl with carbonate is high, it is essential to control the diffusion rate and reaction rate in order to generate the most effective wormholes. In a typical interstitial velocity (vᵢ) to pore volume to breakthrough (PVʙт) graph, there exists an optimal point for each curve at which a given amount of acid creates a wormhole that penetrates deepest into the wellbore. In order to improve the efficiency of acidizing and maximize the impact of the stimulation, acid transport and reaction rates need to be balanced. Both physical and chemical means could achieve this goal. Chemical reduction of reactivity employs various chemicals to inhibit the rapid reaction from taking place. In this study, the wormholing phenomena of three types of novel acid systems were investigated via matrix acidizing coreflood experiments to assess their performance. The results were compared with the performance of conventional 15% HCl. With the experimental data, wormhole length could be calculated with a given volume of acid at their optimal point, as well as reduction in skin and ultimately the impact on production rate. An extensive mathematical modeling of wormhole development was conducted to evaluate their applicability in field scale. The results show that the optimum PVʙт and vᵢ values of the chemically retarded acids were lower than those of 15% HCl. These novel acids generate wormholes more efficiently at lower vi compared to 15% HCl. The mathematical modeling also shows that the novel acids performance is better in terms of productivity increase, wormhole penetration length, and skin reduction

A Survey on the Impact of Operation Volume on Rectal Cancer Management

The rectal cancer management can be influenced by the surgeon's practice and the hospital. This study was to evaluate the differences according to the surgeon's operative volume and the level of the hospital. Questionnaires were sent out to the members of the 'Korean Society of Coloproctology', and the responses were evaluated according to the surgeon's operation volume, the surgeon's age, and the level of the hospital. Sixty responses were received during the three months' period (from August to October 2004). Thirty three respondents (55%) operated more than 50 cases of rectal cancer per year (high-volume surgeons), and 37 respondents (61%) worked at university hospitals or tertiary care facilities (high-level hospitals). The preoperative evaluation with endorectal ultrasonography (ERUS) was significantly different according to the surgeon's operation volume and the level of the hospital, whereas magnetic resonance imaging and positron emission tomography (PET) was significantly different only for the surgeon's operation volume. The preoperative radiation therapy was significantly different according to the surgeon's operation volume, the surgeon's age, and the level of the hospital. However, there was no significant difference found on the operative procedures or postoperative surveillance. The preoperative loco-regional evaluation and the preoperative radiation therapy could be considered as the factors that influence the volume-outcome relationship in rectal cancer treatment

Heterogeneity of Adenosine Triphosphate-Based Chemotherapy Response Assay in Colorectal Cancer - Secondary Publication

PURPOSE: Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) is a well-documented and validated technology that can individualize chemotherapy for patients with lung, stomach, or breast cancer. This study explored the feasibility of ATP-CRA as a chemosensitivity test in patients with colorectal cancer. MATERIALS AND METHODS: A total of 118 patients who underwent surgical resection for colorectal adenocarcinoma were analyzed for chemosensitivity to 6 anticancer drugs using ATP-CRA. We calculated the cell death rate (CDR) by measuring intracellular ATP levels of drug-exposed cells and untreated controls. RESULTS: Interpretable results were available for 85.5% (118/138) of patients. The mean coefficient of variation for triplicate ATP measurements was 9.2%. The highest CDR was observed in irinotecan (34.0%) and the lowest CDR in etoposide (21.0%). Paclitaxel had the broadest range of CDR (0-86.7%) and 5-FU had the narrowest range of CDR (0-56.8%). The overall highest responsiveness was seen most prevalently in irinotecan (24.7%, 23/93 patients). Irinotecan had the greatest responsiveness in patients with well differentiated and moderately differentiated carcinoma. CONCLUSION: Our study suggests that ATP-CRA could be used to identify patients with colorectal cancer who might benefit from treatment with a specific chemotherapeutic agent.ope

The effect of helium-enhanced stellar populations on the ultraviolet-upturn phenomenon of early-type galaxies

Recent observations and modeling of globular clusters with multiple populations strongly indicate the presence of super helium-rich subpopulations in old stellar systems. Motivated by this, we have constructed new population synthesis models with and without helium-enhanced subpopulations to investigate their impact on the UV-upturn phenomenon of quiescent early-type galaxies. We find that our models with helium- enhanced subpopulations can naturally reproduce the strong UV-upturns observed in giant elliptical galaxies assuming an age similar to that of old globular clusters in the Milky Way. The major source of far-UV (FUV) flux, in this model, is relatively metal- poor and helium-enhanced hot horizontal branch stars and their progeny. The Burstein et al. (1988) relation of the F U V - V color with metallicity is also explained either by the variation of the fraction of helium-enhanced subpopulations or by the spread in mean age of stellar populations in early-type galaxies.Comment: 12 pages, 4 figures, 1 table, Accepted for publication in ApJ

Dependent Lung Opacity at Thin-Section CT: Evaluation by Spirometrically-Gated CT of the Influence of Lung Volume

ObjectiveTo evaluate the influence of lung volume on dependent lung opacity seen at thin-section CT.Materials and methodsIn thirteen healthy volunteers, thin-section CT scans were performed at three levels (upper, mid, and lower portion of the lung) and at different lung volumes (10, 30, 50, and 100% vital capacity), using spirometric gated CT. Using a three-point scale, two radiologists determined whether dependent opacity was present, and estimated its degree. Regional lung attenuation at a level 2 cm above the diaphragm was determined using semiautomatic segmentation, and the diameter of a branch of the right lower posterior basal segmental artery was measured at each different vital capacity.ResultsAt all three anatomic levels, dependent opacity occurred significantly more often at lower vital capacities (10, 30%) than at 100% vital capacity (p = 0.001). Visually estimated dependent opacity was significantly related to regional lung attenuation (p < 0.0001), which in dependent areas progressively increased as vital capacity decreased (p < 0.0001). The presence of dependent opacity and regional lung attenuation of a dependent area correlated significantly with increased diameter of a segmental arterial branch (r = 0.493 and p = 0.0002; r = 0.486 and p = 0.0003, respectively).ConclusionVisual estimation and CT measurements of dependent opacity obtained by semiautomatic segmentation are significantly influenced by lung volume and are related to vascular diameter